(00:09:32 Biological Adversity & the Survival Circuit In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. Don't snack. Dr. David Sinclair Social: Lifespan book: https://amzn.to/3sUqurT Call in # 800 450 7876 to participate & listen live See omnystudio.com/listener for privacy information.By Urban One, IN VARIOUS PLACES around the world, strange and otherworldly light phenomena have been witnessed and reported by many people for hundreds of years. In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. (0:21:24) Evidence that Fasting is a Pro-longevity Intervention in Humans For Longevity | Episode 5. A password will be e-mailed to you. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclairOur Patreon page: https://www.patreon.com/davidsinclairTimestamps:(00:00:00) Introducing Episode 3: Exercise Hot Cold(00:01:01) A Pernicisous Element Called Iron(00:02:46) A Quick Primer on Free Radicals(00:05:42) Review of Dietary Takeaways(00:07:01) Sponsors(00:09:32 Biological Adversity & the Survival Circuit(00:13:24) Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin)(00:17:25) Get Off Your Butt(00:19:40) Exercise Protects against Disease & Mortality(00:21:17) Daily Step Count and Walking After Eating(00:22:33) Exercise Activates AMPK and Creates More Mitochondria(00:24:03) Vigorous Exercise, Hypoxia, the Electron Transport Chain(00:28:19) Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation(00:32:13) The Epigenome and Biological Age are Impacted by Exercise(00:36:43) How to Measure your Biological Age(00:37:31) Exercise Recommendations(00:39:28) Wearables and Individualized Health Tracking(00:43:14) The Importance of Weight Training(00:46:08) Physical Activity & Senescent Cells(00:48:01) Wrap-up & Takeaways(00:49:47) Hyperbaric Oxygen Therapy(00:57:24) Cold Therapy(01:03:50) Applying Heat(01:07:04) Adversity Mimetics Produce Endorphins(01:08:07) A Basic Protocol for Mimicking Adversity(01:10:04) Next Week: Molecules & Supplements(01:10:45) Subscription & SupportFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. Lifespan book: https://amzn.to/3sUqurT You are right that proving lifespan extension isn't simple but it's possible. (1:04:12) Obesity, Eating Habits, and Aging (0:15:23) Fasting, mTOR, and AMPK Before we hear from Professor Lusane, Baltimore activist Jovani Patterson talks about the problems in the Baltimore city school system. Can you live a good life even when things are hard? (01:07:37) Todays Takeaways The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. (01:00:18) Skillbatical (01:04:56) Thanking the Podcast Team and Wrapping Up Season One Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. He is an inventor on 35 patents and has received more than 35 awards and honors. The podcast is hosted by journalist Matt Fuchs, editor of the award-winning science outlet Leaps.org. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. (00:00:00) Introducing Episode Eight: The Future of Anti-aging Medicine #593 - Alex DatePsych - Why Is No One Having Sex? Episode 2: Poverty, inequa What causes aging? 13:53 There is no growth , It's Modern Wisdom's 5th birthday!! (00:30:16) Cutting-edge Testing and Biological Age (0:29:42) Focus on Time-restricted Feeding ( 16 Hours of Fasting) The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. (0:08:04) Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy Before we hear from Baba Lumumba, we'll review the increasing rate of Prostate Cancer among Black men. Still, her dad kept finding ways to, as she described, bribe her to share her voice and nurture her creative impulse, often in writing, from poems to stories and beyond. But, what if,, Dr Richard Wrangham is an anthropologist and primatologist, a Professor of Biological Anthropology at Harvard University and an author whose research focuses on ape behaviour, human evolution, violence, and cooking. Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3. To start the program, Baltimore activists Kim Poole & Sister Swatara Olushola live in Rwanda. (00:00:00) Kicking Off Episode Four: Longevity Molecules The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. (00:21:17) Daily Step Count and Walking After Eating The Science of Keeping the Brain Healthy | Episode 7. (0:34:24) Genetics Influence How an Intervention Affects Aging The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. * Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. * Levels - https://levels.link/sinclair Matthew LaPlante's Social: Health has become overcomplicated. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. (00:00:00) Introducing Episode 3: Exercise Hot Cold This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Paul is currently working on a new documentary called 'Wolf Lands', abou, Mark Manson is a best selling author, blogger and a movie star. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser . Journalist A. Peter Bailey, who was at the Audubon Ballroom the evening Malcolm was killed will be in our classroom. Including guests like Dr Jordan Peterson, Jocko Willink, Dr Andrew Huberman, Ryan Holiday, James Clear, Robert Greene, Balaji Srinivasan, Steven Pinker, Alex Hormozi, Douglas Murray, Michael Malice, James Smith, Dr David Sinclair, Mark Manson and more. * InsideTracker - https://insidetracker.com/sinclair (0:58:16) Main Takeaways I aim to simplify it In this podcast, we hear stories from leading health experts and exciting personalities who offer easy health life-hacks, expert advice and debunk common health myths giving you the tools to revolutionise how you eat, sleep, move and relax. Hosted by award-winning journalist Tim Samuels. David Sinclair Social: Instagram Twitter FacebookTo stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.Matthew LaPlante's Social: TwitterTimestamps:(00:00:00) Kicking Off Episode Five: Interventions on the Cutting Edge(00:02:39) Expressing Gratitude to the Sponsors(00:05:28) Testosterone Replacement Therapy(00:10:09) Human Growth Hormone(00:13:56) Peptide Supplementation and Regenerative Signaling(00:18:11) MOTS-c, Humanin, and Other Peptides(00:25:05) Exosome Therapy(00:31:56) A Primer on Stem Cells and Yamanaka Factors(00:37:59) Stem Cell Aging and Cord Blood Banking(00:41:42) The Therapeutic Potential of Stem Cells(00:43:37) Cellular Reprogramming(00:51:35) Resetting the Aging Clock(00:56:50) The Future Looks Bright(00:58:15) Next Weeks Episode: External Aging(00:58:36) Subscription and Support OptionsFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. There are cheat codes to get the brain to believe strange things, do strange things and change in ways you might not anticipate. Before we hear from Professor Ampim, Financial Expert JB Bryan will provide tips on what to do if you unexpectedly , Dr Stephanie Eltz is a Trauma Surgeon and CEO and Co-founder of Doctify, which is basically Yelp/Trustpilot for Doctors. Chris Twitter: https://twitter.com/RealCSharp Chris Instagram: https://www.instagram.com/christopher Liberation Times Twitter: https://twitter.com/LiberationTimes Liberation Times Website: https://www.liberationtimes.com/ SUPPORT DISCLOSURE TEAM !, Paul Sinclair is recognised within the field of unexplained phenomena for his honest no nonsense approach to the subject. To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Dr. Lusane will discuss his book, The Black History of the Whitehouse. Before we hear from Mollie Bell, a report from attorney Malik Shabazz on bringing Emmitt Tillls's accused killer to justice. Our Patreon page: https://www.patreon.com/davidsinclair (00:45:42) Hair Loss and Hair Graying (00:03:14) Goal of the Lifespan Podcast To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. How to Turn Anxiety Into a Superpower | Dr. Wendy Suzuki, Griot Baba Lumumba, Dr. Arthur Burnett & Dr. Segun Adebayo l The Carl Nelson Show, #113 Mental Models for Health Entrepreneurship Dr Ignacio Medrano (CEO Savana), A. Peter Bailey, Simeon Booker Muhammad & Senghor Baye l The Carl Nelson Show, #338 The Secrets To Living Your Longest, Healthiest Life with Dr Mark Hyman, #159 Dr. Anna Lembke: Between Pleasure and Pain, Dr. Clarence Lusane, Jovani Patterson & Sinclair Skinner l The Carl Nelson Show, #592 - Richard Shotton - 8 Fascinating Psychological Biases, How to Finish What Matters & Get More Free Time | Spotlight Convo. In the guest interview series Marisa speaks with mindset and success experts including Gabby Bernstein, L Making Sense of Science features interviews with leading medical and scientific experts about the latest developments in health innovation and the big ethical and social questions they raise. You're supposed to leave the juvenile patterns and beliefs and behaviours behind as you shed your past self like a wise awakened crab. To get, Dr Ignacio Medrano is the Founder of Savana (raised $44M dollars with over 100 employees). * Instagram Yeah, weve all been there on some level. Biotracking, Age Reversal & Other Advanced Health Technologies, Medical Interventions (TRT, HGH, Stem Cells, etc.) For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. (0:38:44) Intermittent Fasting with Adequate Nutrition (IFAN) Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. They use AI to unlock all the value out of clinical records and produce real world evidence. In this week's episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. He prefers to follow the research wherever that may lead, even if it means putting himself in locations and situations most people would not want to be in. To celebrate, I asked for questions from YouTube, Twitter, Locals and Instagram, so here's another 90 minutes of me trying to answer as many as possible. Thank you to our sponsors: (00:07:38) Ex-differentiation as a Driver of Aging Our Patreon page: (0:47:53) Plant-Based Diets Protect Against Aging (00:36:40) Using Personalized Data to Inform your Diet The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels. The Science of Looking Younger, Longer | Episode 6. Guests: Labours Jon Cruddas MP; human rights activist Peter Tatchell; ConservativeHome editor Jonathan Isaby, psephologist Professor John Curtice; Dr Madsen Pirie, Director of the free-market Adam Smith Institute; LibDem Voice editor Stephen Tall; David Babbs of campaign organisation 38 Degrees, and the New Statesmans Laurie Penny. You're not supposed to just get older, you're supposed to mature as well. David Sinclair's Post David Sinclair Experienced In-house Counsel, Polar Expedition Leader/Guide, Nature Photographer, Founder and Director - Islands and Ice Travel 2w Edited Report this post . The investigation was filmed and released , I hit 700k Subscribers on YouTube!! (00:06:48) Modern Healthcare, Disease Detection, and Circulating DNA * Twitter The health entrepreneurship podcast focusing on big picture stuff. (00:32:13) The Epigenome and Biological Age are Impacted by Exercise * Facebook Cole Arthur Riley | Reclaiming the Stories That Shape Us, Mollie Bell, Attorney Malik Shabazz, Relationship Expert Renee Miller, Activists Kim Poole & Sister Swatara Olushola l The Carl Nelson Show, #336 How Trauma Impacts Your Physical Health & How To Heal From It with Dr Bessel van der Kolk, Professor Manu Ampim & Financial Expert JB Bryan l The Carl Nelson Show, #112 Yelp for Doctors Dr Stephanie Eltz (CEO Doctify), #589 - 14 Lessons from 5 Years Of Modern Wisdom, How to Identify & Heal Your Origin Wound (we all have them) | Vienna Pharaon. For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Multiple voices, one phenomenon. Join us as host Shane Parrish uncovers the timeless lessons and insights you can use to get lasting results. (0043:08) Fisetin and Quercetin Matthew LaPlante's Social: Harnessing this knowledge, he was able to reverse this process, making mice younger, according to the study published in the journal Cell. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. Midland Cares mission: meeting individual needs through innovative care solutions. massage west hollywood. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Can you do an episode on pain and pain management?Please provide more references and explanation to each abbreviation. 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