Pharmacol. Lianhua Qingwen - Wikipedia Despite the ban, Lianhua Qingwen has been sold illegally in Australia as a COVID-19 treatment.[21]. Impressively, LHQW in conjunction with conventional treatment could significantly improve COVID-19 patients as a synergetic strategy. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. LQ15H280003), the Clinical Research Projects of Zhejiang Medical Association (No. There was no statistically significant difference in the incidence of hepatobiliary system damage between the LHQW group and the conventional drug group (RR = 0.86, 95% CI = 0.581.28, p = 0.461). However, since subgroup and sensitivity analyses did not explore the source of heterogeneity, we utilized meta-regression to determine the potential underlying factors. Pharmacokinetics-based identification of pseudoaldosterogenic compounds In addition, LHQW had antagonist effects on the pulmonary oxidative lesions that induced by fine particulates PM2.5 in rats [34]. Mo H.Y., Yang Z.F., Zheng J.P., Mo Z.Y., Li Y.M., Xiao Z.L. Accordingly, other biases were defined as low risk of bias. The risk of bias data is presented as a percentage, as shown in Figure 2. Efficacy of Lianhua Qingwen Compared With Conventional Drugs in the Treatment of Common Pneumonia and Covid-19 Pneumonia: a Meta-Analysis. Plants of the World Online. With gradual improvement of the adverse drug reaction monitoring system of China, reports of adverse reactions or events have increased. MANILA, Philippines The Makati Medical Center's therapeutics and medication safety committee (TMSC) has said that the Chinese drug, Lianhua Qingwen (LQ), should not be taken without a doctor's prescription to ease new coronavirus disease (COVID-19) symptoms, warning that it may do more harm than good. Hence, the researches on specific active components of LHQW are still important and the reduction of irrelevant ingredients may be related to less adverse reactions. The novel coronavirus disease 2019 (COVID-19) has become a matter of international concern as the disease is spreading exponentially. Both Lian-Hua-Qing-Wen Capsule (LHQWC) and Jin-Hua-Qing . Lianhua Qingwen (LHQW) is a classical Chinese medical preparation, while one of its prescription compositions Maxingshigan Decoction has a history of more than thousand years to treat plague, and exhibits antiviral and lung protection actions [15,16]. Inclusion in an NLM database does not imply endorsement of, or agreement with, Yiling Pharmaceutical (2021). Traditional Chinese medicine Lianhua Qingwen capsule has been proven effective for the treatment of COVID-19, China's top respiratory expert Zhong Nanshan said in a webinar with overseas Chinese students on Monday. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Frontiers | Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule doi:10.13412/j.cnki.zyyl.2010.06.026. 367 (6485), 14121413. Lianhua Qingwen Capsules of Yiling Pharmaceutical Approved in mauritius. Study design was done by CH and BH. Heterogeneity was evaluated using I2 statistic. Finally, our data showed that LHQW reduces the incidence of a number of adverse reactions compared with conventional drugs. doi:10.3969/j.issn.1672-2809.2020.13.020, Liu, C. Y., Li, X. Q., and Cai, S. Q. Bethesda, MD 20894, Web Policies However, while the potential clinical efficacy of LHQW has been demonstrated in several studies (Hu et al., 2020; Wu et al., 2020; Xiao et al., 2020; Wang et al., 2021), no consensus has been reached regarding the adverse reactions associated with LHQW therapy to date. Yao K.T., Liu M.Y., Li X., Huang J.H., Cai H.B. The recent network pharmacology studies showed that the effects of LHQW prescription was related to virus infection, inflammation and immunity, moreover, its main active ingredients were verified by molecular docking with angiotensin-converting enzyme 2 (ACE2), one receptor of SARS-CoV-2, so as to have a therapeutic effect on COVID-19 [[27], [28], [29]]. Current evidence shows that Lianhua Qingwen capsule is more effective and safer than Oseltamivir, Ribavirin and Ankahuangmin capsules. In the Philippines, its Food and Drug Administration approved Lianhua Qingwen on 7 August 2020 as a traditional herbal product that helps remove "heat-toxin invasion of the lungs, including symptoms such as fever, aversion to cold, muscle soreness, stuffy and runny nose". aimed to assess the efficacy and safety of LH combined with usual treatment vs usual treatment alone in treating mild or moderate COVID-19 by a meta-analysis of randomized controlled trials (RCTs). (2020). (2021). Cheng D.Z., Wang W.J., Li Y., Wu X.D., Zhou B., Song Q.Y. Similar results were obtained in subgroup analysis of hepatic function abnormal and transaminase increased. Retrospective clinical analysis on treatment of coronavirus disease 2019 with traditional Chinese medicine Lianhua Qingwen. Sensitivity analysis was performed by assessing the stability of the results after removal of individual studies. [Saururaceae; Houttuyniae Botanical drug], a composition of LHQW (Huang et al., 2021), that contains allergenic ingredients, such as chlorogenic acid, as well as the unstable nature of houttuyfonate, which can cause adverse reactions (Cao, 2016). The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author. First, the quality of qualified studies was generally medium, randomization procedures and blinding information were lacking in most studies. FOIA Seven studies reported the adverse reactions of hepatobiliary system damage. [citation needed]. Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19. Comprehensive analysis of influenza may provide a significant advantage in generalization of the conclusions. COVID-19 has led to a great case fatality. Its effects are partly due to its regulation on immunity functions, and inhibitory effects on virus replication and pro-inflammatory cytokines release. 52 (3), 5860. Among the 13 included studies on treatment of hand-foot-mouth disease, eight reported adverse reactions. Reports emerged indicating that this process consumed significant logistical capacity, drawing criticism about misuse of resources at a time when people were struggling with shortages of basic needs such as food and medication. Liu-Cheng Li was responsible for drafting the manuscript. Lianhuaqingwencaps.com - 608667 - 07/06/2020 | FDA [Cruciferae; Isatudus Radix], Dryopteris crassirhizoma Nakai [Polypodiaceae; Dryopteris Crassirhizomatis Rhizoma], Houttuynia cordata Thunb. Efficacy and Safety of Lianhua Qingwen Granule Combined with Oseltamivir in the Treatment of Influenza Virus Infection in Children. As adverse reactions in COVID-19 pneumonia and chronic obstructive pulmonary disease treatment were only reported for a limited number of studies, no sensitivity analysis for these diseases was conducted. Fig. LHQW capsules also showed a multi-access effects on anti-human influenza A virus H3N2, including the prevention effect on virus adsorption, inhibition on virus proliferation after adsorption and direct killing of the virus [25]. Chinese Herbal Medicine ("3 Medicines and 3 Formulations") for COVID 19: Rapid Systematic Review and MetaanalysisChinese Herbal Medicine ("3 Medicines and 3 Formulations") for COVID-19: Rapid Systematic Review and Meta-Analysis. Lianhua Qingwen Dosage & Drug Information | MIMS Thailand In another prospective multicenter randomized controlled trial in confirmed COVID-19 cases, Hu et al. Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial. The Plant List (2021). The term adverse reaction represents any undesired and unintended response that occurs with normal drug use (Gallelli et al., 2002). The official monograph of LHQW states that the adverse effects are "unclear". Yiling Pharmaceutical (2020). LHQW capsules not only had hemagglutination inhibition activity against B/Guangzhou/0215/2012 of influenza B virus, but also inhibited the over-expression of RANTES, IL-6, IL-8, IP-10, TNF-, MCP-1, macrophage inflammatory protein (MIP)-1, and interferon (IFN)- at the mRNA level and prevented a severe inflammatory response [26]. Literature analysis of clinical application and adverse drug reaction/event of Lianhua Qingwen capsule. Lianhua Qingwen (LHQW) is a commonly used Chinese medical preparation to treat viral influenza, including in the fight against SARS in 20022003 in China. TABLE 2. This work was supported by the National Natural Science Foundation of China (No. the contents by NLM or the National Institutes of Health. Lianhua-qingwen Displays Antiviral and Anti-inflammatory Activity and Synergistic Effects with Oseltamivir against Influenza B Virus Infection in the Mouse Model. We hope this review will not only present comprehensive evidence for LHQW use in COVID-19 therapy, but also fuel antiviral researches and put forward promising insights for further antiviral drug development. Language links are at the top of the page across from the title. Common side effects are heart palpitations, nausea, and vomiting. Six studies were included on treatment of herpes zoster and reported the adverse reactions. We would like to express our appreciation to all authors of eligible studies which were included in the current meta-analysis. 04:26. Pharmacol. The China National Medical Products Administration agency has officially approved LHQW for the treatment of mild or ordinary COVID-19 pneumonia (Ahsan et al., 2020; Cao et al., 2020; Chan et al., 2020; Khan et al., 2020; Kupferschmidt and Cohen, 2020). *Correspondence: Guoliang Zhang, zhangguoliang61@sina.com, These authors have contributed equally to this work, https://doi.org/10.3389/fphar.2022.764774, World Health Organization Adverse Drug Reaction Terminology (2009), https://www.frontiersin.org/articles/10.3389/fphar.2022.764774/full#supplementary-material, http://m.news.cctv.com/2020/03/17/ARTIEYQ2aws8fPYWQxjnynzo200317.shtml?from=singlemessage, https://mpns.science.kew.org/mpns-portal/, https://chemrxiv.org/engage/chemrxiv/article-details/60c74908ee301c485bc799cf, http://www.yiling.cn/contents/75/132.html. Available at: http://www.yiling.cn/contents/75/132.html (Accessed September 14, 2021). Seven studies reporting treatment of chronic obstructive pulmonary disease were included, among which two described adverse reactions. Systematic Review Registration: https://clinicaltrials.gov/, CRD-42020224180. Modern pharmacological studies have shown that Lianhua Qingwen Prescription, as a traditional Chinese medicine prescription, has extensive antiviral and immunomodulatory effects on a series of influenza viruses. Patients with severe cases will develop acute respiratory distress syndrome and septic shock, and eventually develop multi-organ failure and death [5]. Ling X.Y., Tao J.L., Sun X., Yuan B. H. Ohba [Crassulaceae; Rhodiolae Crenulatae Radix et Rhizoma] (85g), Mentha haplocalyx Briq. In mice after infected with the flu virus FM1, LHQW capsule obviously increased IFN- content in lung homogenate and significantly reduced the levels of TNF-, IL-1 and IL-6 in lung tissues, and had inhibiting effect on the marked decrease of CD4+ and CD4+/CD8+ [31,32]. Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. FDA Advisory No.2021-0723 - Food and Drug Administration 14 (2), 6772. As the Financial Times report showed, these appeared to be serious conflicts of interest as the investments benefited from the PRC and HK governments' rapid approval and then widespread national & international promotion of Lianhua Qingwen and other suspect treatments for purportedly helping COVID-19 sufferers. LHQW had been proven to accelerate the improvement of acute exacerbation of COPD (AECOPD) patients, especially for the high-risk subgroup, due to the decreased release of inflammatory mediators including IL-8, TNF- , IL-17, and IL-23 [38]. Moreover, LHQW capsule also remarkably decreased the infectivity of H3N2 in vitro [25]. Role of LHQW in the treatment of COVID-19. Cheng D.Z., Li Y. The control and improvement of the present COVID-19 situation in China could not be separated from the extensive participation of TCM, which has been proven effective by the clinical studies in COVID-19 patients [41,44,48,49]. There was no statistically significant difference in the incidence of adverse reactions during treatment of herpes zoster between the LHQW group and the conventional drug group (RR = 0.80, 95% CI = 0.521.23, p = 0.302). There was no statistically significant difference in the incidence of psychiatric disorders between the LHQW group and the conventional drug group (RR = 1.00, 95% CI = 0.253.97, p = 1.000). Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial. 12 (08), 140141. There was a reduced risk of skin and its appendage damage in the LHQW group compared to the conventional drug group (RR = 0.63, 95% CI = 0.440.92, p = 0.015). Systematic review of efficacy and safety of Lianhua Qingwen capsules in treatment of viral influenza. Multiple clinical observations of Lianhua Qingwen combined with conventional treatment can increase the disappearance rate of major symptoms of NCP (fever, cough, fatigue) and other symptoms (chest tightness, dyspnea, and loss of appetite), and reduce the proportion of severe symptoms. The Trim and Fill method was further applied to assess the impact of publication bias. Drug Related Hospital Admissions: the Role of Definitions and Intensity of Data Collection, and the Possibility of Prevention. The following terms were searched using the title, abstract or keywords in the English databases: Lianhuaqinwen granule, Lianhuaqinwen capsule, Lianhua Qingwen capsule/granule. For the Chinese databases, the search terms used were: , , /.. Yang C.X., Qu J., Liu Y.T., Meng S.W., Wang B.L., Feng M.Q., Sun Y. 3.2.2. Nevertheless, pressing researches should be conducted to illuminate the unconfirmed effects, regulatory mechanisms and adverse reactions of LHQW in treating COVID-19. While the results from our study showed that LHQW has a potentially reduced incidence of adverse reactions in certain diseases and symptoms to a greater extent than conventional treatment, efficacy is an important consideration that should not be overlooked. "It's the first time in the world that we have enough evidence to prove Lianhua Qingwen capsule is effective and can help . Subgroup analysis additionally revealed a reduced incidence of some adverse reactions in the LHQW group compared to the conventional drug group (Rash of skin and its appendage damage, dizziness or headache owing to nervous system damage, nausea or vomiting from gastrointestinal system damage and resurgence of disease from other adverse reactions).
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